Targeting Brain Inflammation to Treat Methamphetamine Addiction, Keith Heinzerling, MD | UCLAMDChat

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Targeting Brain Inflammation to Treat Methamphetamine Addiction, Keith Heinzerling, MD | UCLAMDChat 4.5

UCLA addiction and internal medicine physician Keith Heinzerling, MD., medical director of the UCLA Center for Behavioral and Addiction Medicine, discusses new research aimed at reducing brain inflammation to improve brain function and reduce relapse in patients being treated for methamphetamine addiction.

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i quit meth without treatment didn't like what it did to my whole family

Author — Dell Hatley


The reason you can't fix most addictions is because you are going about it backwards, you are trying to cure the addiction instead of the actual cause of the addiction. Most addictions are formed because there is already something wrong to begin with. This is why some people are more prone to become addicts than others and why some addicts can abstain from their addiction and some cannot. Will power only plays a small part in abstaining for good. People get addicted to drugs because usually there is something they're not getting enough of naturally to begin with. People with low energy & motivation will obviously become addicted much easily to meth & cocaine than people with normal energy and motivation because they're bodies are already lacking in that area, if they ever try using stimulants they will quickly start to crave & need these stimulants to function because they were already lacking in this area to begin with. By trying to fix the initial cause/reasons of why they were lacking the energy/motivation in the first place instead of trying to cure their addiction will have more success in relapsing. This is my opinion speaking from personal experience.

Author — tink14


Way to go UCLA glad to see that you guys are working on actually helping theses issues.

Author — Grace Bayan


This guy really gets it, fix the chemical problem and then you can use traditional methods to their fullfullest effect.

Author — Carlin Lentz


Interesting stuff. Hope for help is always good. Any one struggling with addiction should look up fasterEFT here on YouTube. It's amazing.

Author — Jen Clark


This study is 5 years old. How much progress have you made on calming the brain inflammation that this insidious drug causes?

Author — Margaret Adams


I hate this drug its messing my cousin up

Author — Coast2Soul Music


I just want to thank Dr. Heinzlinger
for all that you do to help people who suffer from addiction. I am a functional addict of 32 years. Dr Heinzlingers video on inflammation in the brain and meth addiction was extremely enlightening. I am having every symptom of relapsing MS. I have tried every recovery method, Im so close to just giving up but you have given me hope. Thank you sir, you are a true healer.
* Day 2 of recovery from Meth *

Author — Victoria Harshman


Thank you for sharing this video doctor! you saved a lot of life.

Author — Marrk Ricco


EaRtHING is very good for inflammation!!!

Author — Yon Kromis


I need help is your organization still up? :(

Author — james larga


So what I gather from part of this is that inpatient treatment has a higher recidivism rate than out patient.

Author — Bugale13


Great lecture. What a Nice doctor and very smart too.

Author — Laurie Deering


Does Herpes viruses (like hsv1&2, hhv 3 (shingles), hhv4 (ebv) hhv5 (cmv), hhv6a&b, and hhv 7&8) add to the brain inflammation like HIV does with meth?

Author — Michael David Caprarella


do research on using modafinil to help meth addicts stay away from relapsing

Author — leroymanoza


I need someone to rescue me I am desperate please someone help me I’m dying

Author — David Figueroa


this is great if it works and after reading many comments all around help is helpful for a person choosing recovery who has had difficulties staying clean and sober.dont give up.

Author — bobbi barlow


Hi does meth affect Rhuematoid arthritis patient.does meth are the responsible /root cause of RA ..of the joints inflamation and flare ups.

Author — Arnie Penarubia


Does the liver and kidneys get affected by ibudilast in a negative way?

Author — Nina Johnson


LDN works wonders for meth recovery , . google it.
Researchers from the University of California – Los Angeles tested the drug, Naltrexone, in 22 men and eight women who used methamphetamine three to four days a week on average. The drug blocks opioid receptors to help reduce the “high” that users experience from alcohol, and in this instance, meth. The study was published in the journal Neuropsychopharmacology.

The participants completed two four-day hospital stays where they were given either Naltrexone (25mg first two days, 50mg third and fourth day) or placebo. Ten days after the first stay, participants were readmitted for the second four-day stay and were given the opposite therapy. On the last day of the cycle, participants were given an intravenous dose of methamphetamine. Researchers evaluated their state three hours after injection.

Overall, Naltrexone significantly reduced participants’ craving for and arousal by methamphetamine. Compared to when using Naltrexone, participants’ heart rates and pulse readings were much higher when given placebo. People taking Naltrexone also had lower heart rates and pulse readings when presented with drug paraphernalia compared to people taking placebo, indicating that the drug reduced the rewarding effects of methamphetamine.

The drug was well-tolerated and had minimal side effects, and was effective in both men and women, although positive effects in men seemed be slightly smaller. The timing of Naltrexone administration (first or second hospital stay) did not affect outcomes.

The researchers, along with support from the National Institute on Drug Abuse and UCLA’s Clinical and Translational Science Institute, are now conducting clinical trials to further evaluate Naltrexone’s effectiveness in people addicted to methamphetamine and test whether higher doses or combinations of the drug with other therapies would be more effective.

Author — Jim Jones