Vasopressors and Vitamin C in Sepsis Explained Clearly

  • 🎬 Video
  • ℹ️ Description
Vasopressors and Vitamin C in Sepsis Explained Clearly 5

In Vasopressors Explained Clearly, renowned instructor Dr. Roger Seheult illustrates a concise way to understand vasopressors & inotropes, and how to systematically manage patients with hypotension & septic shock.

𝐂𝐨𝐦𝐩𝐥𝐞𝐭𝐞 𝐜𝐨𝐮𝐫𝐬𝐞 𝐢𝐧𝐜𝐥𝐮𝐝𝐞𝐬 𝐭𝐡𝐞 𝐟𝐨𝐥𝐥𝐨𝐰𝐢𝐧𝐠:
- A thorough comparison of each vasopressor + key differences: levophed, epinephrine, vasopressin, neosynephrine, dopamine, dobutamine, etc.
- Key physiology of endogenous vs. exogenous vasopressors
- Illustrations of the receptors involved in mediating blood pressure
- A systematic approach to managing hypotension and septic shock.
- Side effects of vasopressors and inotropes
- Central line vs. alternative options for administration.
- A clinical perspective of tips, nuances, & practice scenarios.
- Quiz questions to reinforce core concepts and help you study

𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 𝗼𝗳 𝘁𝗵𝗶𝘀 𝘃𝗶𝗱𝗲𝗼 𝗶𝗻𝗰𝗹𝘂𝗱𝗲:

- Core vasopressor physiology
- The synthetic pathway for dopamine, norepinephrine, and epinephrine (includes tyrosine and L DOPA)
- Vitamin C and the Marik Protocol
- Limitations of studies that are not randomized, placebo-controlled

Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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Recommended Audience - Medical professionals and medical students: including physicians, nurse practitioners, physician assistants, nurses, respiratory therapists, EMT and paramedics, and many others. Review and test prep for USMLE, MCAT, PANCE, NCLEX, NAPLEX, NBDE, RN, RT, MD, DO, PA, NP school and board examinations.

Produced by Kyle Allred PA-C

Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider.

💬 Comments on the video

My mother went into septic shock, her doctor used a cocktail of Vit C, zinc and thiamine..she survived.

Author — Jessica Fernandez


Why the hell did they stop the vitamin C after 4 days. Vitamin C experts will tell you that you should continue which vitamin C until the infection has cleared up.

You give vitamin C for 4 days and starts doing it's job clearing up the infection and then you stop it before the infection has gone. That just doesn't make any sense.

Author — Danger Zone


Thank you Dr. Roger! clinical trial VICTAS with n = 2000 people ends in December 2019. Looking forward for the results, hope for positive ones!

Author — Mukhtar Sadykov


Dr. Seheult, do you think this has applications for ARDS as well? I was unfamiliar with ascorbic acid being a cofactor in the catecholamine pathway (biochemistry was 1998 for me!) I believe I have heard Dr. Marik say it reduced the cytokine storm of sepsis.

Author — Sal Livreri


Again we have another misconception dominating the thinking of main stream medicine. That Vitamin C causes kidney stones. It doesn't. 1500 mg ? How about 100, 000 mg. When are you guys going to wake up or get out of the way.

Author — Lawrence Baxa


It's hilarious the way he tip toes around VitC like he's walking on eggshells. The 'great taboo'. Let's be clear, high dose intravenous VitC starts at around 25, 000 mgms/day and finishes at 100, 000mgms/day. Vets would use 1, 500mgms on a sick guinea pig.

Author — 88RJA


Excellent presentation and congrats for using this therapy.

Author — MA4TU2


Will you do one on DIC, HIT, and other clotting diaorders

Author — Don Gemus


Hi, first of all great work with your videos. It whould be nice to see an update of this Video now that Victacs Trial is out. Best regards



Very much looking forward to the results of this study. I hope this is something that will be implemented globally, if it works as well as we hope it does.

Author — Shade Tree Cardiology


lost a friend other day. they were not aware of this. i had a hunch but did not have full information due to lack of time. now I am seeing. but the case was very difficult as he was a cancer patient. it might have helped and was no harm in trying.

Author — king_has_no_cloths kul


High dose C is an antioxidant that also promotes destruction of cancer DNA via the Fenton Reaction. Fortunately, it doesn't contraindicate chemo. Many doctors hypothesis that it does but it doesn't. In fact, it's shown to double the killing effects of chemo in many cancer cell lines. High dose C intravenous isn't magical. It's hard science and it works. One day, I predict medical doctors will be using a slurry of anti-oxidants mixed together for treatments of many acute problems including brain trauma.

Author — JaneFonda1942 Apex Clan


B12 lowers homocysteine and helps vit.C

Author — phanupong asvakiat


Does "Q6 hour" mean "every 6th hour"?

Author — genius4themostpart


The square of possibilities is used to explain Pascal's wager too. There is no harm in a wager that God exist, and living as if one believes.

Author — Sean Rhoades


I would like to know how much longer it takes for Vit. C to increase epinephrine. If it takes long wouldn’t that be a risk to the patient? Also, I’m not sure of the patho of it, but couldn’t lack of epi be due to other reasons besides lack of Vit. C?

Author — Mackdaknife6669


No Benefit to Hydrocortisone, Thiamine, and Vitamin C for Patients with Septic Shock

Patricia Kritek, MD reviewing Fujii T et al. JAMA 2020 Jan 17

Can you update us on this recent article in JAMA concerning Vit C and Septic shock or Marik protocol?

Thank you.

Author — Thai Le


Do you want to update this after the VITAMINS Randomized Clinical Trial results?

Author — capt67usa


The outcome of the study of Marik is even more extreme.
What is mentioned is hospital mortality, then 4 patients in the group receiving the protocol died, but they died of the disease they already had, they didn't die of sepsis.
Therefore in the comparison the mortality of sepsis was 0 in the Vit C group
What we have here is a 100% relation.
Then statistics play no role.

This would work against the Corona virus as well, by the way, since Vit C is also effective to fight viral disease.
An epidemic could be stopped in its tracks this way, don't you think, dr. Seheult?

Author — Richard van der Poort


The rtc is useless unless Dr Mariks protocol is followed to the letter.

Author — Don Sprague